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  • Environmental and occupational exposure to Resorcinol (cas 108-46-3) in Finland

  • Add time:08/21/2019    Source:sciencedirect.com

    Resorcinol (cas 108-46-3) is a suspected endocrine disruptor that affects thyroid function by inhibiting thyroxin peroxidase. It may also have an impact on iodine uptake. Resorcinol has various uses; for example in the manufacture of rubber products and in wood adhesives, flame retardants, UV stabilizers, and dyes. It is also used in personal care products such as hair colorants, anti-acne preparations, and peels.The aim of this study was to assess both environmental background exposure and occupational exposure to resorcinol in Finland. We investigated occupational exposure in hairdresser work and in the manufacture of tyres, adhesive resins and glue-laminated timber by biomonitoring total resorcinol concentration in urine samples. The biomonitoring results were compared to the urinary levels of occupationally non-exposed volunteers, and to the biomonitoring equivalent (BE), which we estimated on the basis of the EFSA’s acceptable daily intake (ADI) value for resorcinol.Almost all the urine samples (99%) of the non-occupationally exposed volunteers contained measurable amounts of resorcinol. The urinary resorcinol data were rather scattered, and the resorcinol concentrations among women (GM 84 μg/l, 95th percentile 2072 μg/l) were clearly higher than the respective concentrations among men (GM 35 μg/l, 95th percentile 587 μg/l). The reason for this difference remains unclear. Although the two highest results exceeded the BE of 4 mg/l calculated on the basis of the EFSA’s ADI, the 95th percentile of the occupationally non-exposed volunteers’ results remained well below the BE among both males and females.According to the results, hairdressers’ exposure to resorcinol was at the same level as that of the reference population of occupationally non-exposed volunteers. All hairdresser’s values remained below the BE for resorcinol.The urinary resorcinol levels of the industrial workers were also at the same level as those of the reference population. We observed slight increases in the post-shift and evening samples of those working in the manufacture of tyres and adhesive resins. The results of some workers in the tyre manufacturing company exceeded the 95th percentile of non-occupationally exposed males, which was used as a biological guidance value for occupational exposure. Moreover, in this case exposure was below the health-based biomonitoring equivalents. All the air samples collected in the companies contained very low resorcinol concentrations. It should be noted that the sample sizes for the male controls and industrial groups were small.

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