Regular paperEnantiomeric determination of amino compounds with high sensitivity using the chiral reagents (+)- and (−)-1-(9-anthryl)-2-Propyl chloroformate (cas 109-61-5)

Add time:08/20/2019    Source:sciencedirect.com

New chiral precolumn reagents, (+)- and (−)-1-(9-anthryl)-2-propyl chloroformate (APOC), are introduced for the chiral separation of amino acids and small peptides in capillary electrophoresis. Chiral separation of 17 amino acids and four small peptides as their diastereomeric 1-(9-anthryl)-2-propyl carbamate derivatives have been achieved by micellar electrokinetic chromatography. The detection limit for the derivatives is in the femtomole range with UV detection and in the attomole range with laser-induced fluorescence (LIF) detection. LIF detection was used to determine the enantiomeric excess of four APOC-derivatised peptides. The use of the new, anthracene-based reagents in conjuction with argon ion LIF makers enantiomeric determinations at ppm levels feasible. In this paper determinations below promille levels are performed without overloading the separation system.

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