Analysis of the purinyl-6-histamine binding to ribonucleic acids☆
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Add time:08/20/2019 Source:sciencedirect.com
Purinyl-6-histamine, which is selectively cytotoxic to tumour cells in tissue culture, does not inhibit the incorporation of precursors of macromolecular syntheses into acid insoluble material of ascites tumour cells in vitro, but it is bound to RNA within cells and to isolated RNA in vitro, as demonstrated by sedimentation studies, Sephadex G50 chromatography, polyacrylamide gel eclectrophoresis and Millipore filtration. The intrinsic binding constant for the binding to isolated RNA is in the order of 103 × M−1 (0.1 M NaCl). There is some evidence (P ≦ 0.1) that purinyl-6-histamine has a higher affinity in ascites tumour RNA and yeast sRNA than to liver RNA.
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