The pathway of catabolism of cytotoxic purinyl-6-substituted amines in vivo
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Add time:08/22/2019 Source:sciencedirect.com
14C-labelled purinyl-6-histamine is catabolized in vivo in the same way as in vitro. The main metabolites are 2,8-dihydroxy-purinyl-derivatives, carbon-dioxide and a product in which the imidazole ring of the purine ring system is opened. The speed of catabolism, the incorporation of produced carbon-dioxide into adenine and guanine, and the inhibition of the catabolism by allo-purinol has been measured.
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