Synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1H)-one derivatives using trifluoroacetimidoyl chlorides

Add time:07/13/2019    Source:sciencedirect.com

A simple protocol is described for the synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1H)-one derivatives. The reaction between diverse 2-chloro-3-acetyl-quinolines with trifluoroacetimidoyl chlorides using sodium hydride in THF at room temperature gives directly the title compounds without isolation of intermediates. Starting 2-chloro-3-acetyl-quinolines were easily prepared in two steps from readily available 2-chloro-3-formyl-quinolines.

We also recommend Trading Suppliers and Manufacturers of Chloro[4-(trifluoromethyl)phenyl]magnesium (cas 2923-41-3). Pls Click Website Link as below: cas 2923-41-3 suppliers

Prev:Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors
Next:Regioselective and reductive cleavage of allyl ethers by NaBH4–HOAc)