Synthesis and antifungal properties of N-[(1,1′-biphenyl)-4-ylmethyl]-1H-imidazol-1-amine derivatives

Add time:08/20/2019    Source:sciencedirect.com

In the course of a study on 1H-imidazol-1-amine derivatives as antifungal agents, we found that N-[(1,1′-biphenyl)-4-ylmethyl]-N-[(2,4-dichlorophenyl)methyl]-1H-imidazol-1-amine (1a) exhibited promising activities. In order to explore more in detail the structure–activity relationship of this new class of antifungal agents, we report now the synthesis and the biological activity of new analogues (1b–k) of compound 1a. The synthesis was performed using N-[(1,1′-biphenyl)-4-ylmethyl]-1H-imidazol-1-amine as starting material which was reacted with the proper arylmethyl halide. Most of the newly synthesized imidazolamines exhibited both fungal growth inhibition activity and cellular selectivity.

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