Diastereoselective scalable synthesis of 2,6-trans-Piperidine (cas 110-89-4)s using an aza-Michael reaction
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Add time:08/27/2019 Source:sciencedirect.com
Highly efficient substrate and reagent controlled stereoselective synthesis of 2,6-trans-piperidine derivative (1) using an aza-Michael reaction is reported. This method was utilized to synthesize a variety of trans-piperidines on hundred-gram scales.
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