Pharmacology letter Accelerated communicationEffect of DOTHIEPIN (cas 113-53-1) on gastric ulceration mediated by lipid derived eicosanoids

Add time:08/26/2019    Source:sciencedirect.com

DOTHIEPIN (cas 113-53-1), a tricyclic antidepressant, significantly inhibited the development of gastric ulcers induced by alcohol, aspirin, indomethacin and Shay's pyloric ligation. Antisecretory studies in pyloric ligated rats revealed that the drug at a dose of 100 mg/kg significantly reduced total acidity, gastric output and protein content. In another set of experiments, dothiepin significantly reduced gastric output, total acidity and protein content in pyloric ligated rats which received 50% alcohol (v/v) 30 minutes after the administration of dothiepin.

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