Short communicationEffects of DOTHIEPIN (cas 113-53-1) on nociceptive flexion reflex and diffuse noxious inhibitory controls in humans

Add time:08/28/2019    Source:sciencedirect.com

The analgesic activity of DOTHIEPIN (cas 113-53-1) (an antidepressant interacting with serotonin receptors) was studied (double-blind) in humans. A significant increase in nociceptive flexion reflex threshold and subjective pain threshold was observed after a 14-day dothiepin treatment. The effects of dothiepin on diffuse noxious inhibitory controls were also investigated using the cold-pressor test as conditioning stimuli. After dothiepin a reduced inhibition of nociceptive flexion reflex during the cold-pressor test and a significant facilitation immediately after the cold-pressor test were observed, while the subjective pain perception was normally inhibited. Our data suggest a serotonergic modulation of diffuse noxious inhibitory controls in humans.

We also recommend Trading Suppliers and Manufacturers of DOTHIEPIN (cas 113-53-1). Pls Click Website Link as below: cas 113-53-1 suppliers

Prev:ORIGINAL ARTICLEUse of alizarin red S as a chromogenic agent for the colorimetric determination of DOTHIEPIN (cas 113-53-1) hydrochloride in pharmaceutical formulations
Next:Molecular and cellular pharmacologyThioxanthenes, Chlorprothixene (cas 113-59-7) and flupentixol inhibit proton currents in BV2 microglial cells)