Research paperβ,γ-diamino acids as building blocks for new analogues of Gramicidin S: Synthesis and biological activity

Add time:08/23/2019    Source:sciencedirect.com

We describe here the synthesis and biological activity study of a pair of diastereomeric analogues of Gramicidin S using β,γ-diamino acids as β-turn mimic. The synthesis of the orthogonally protected β,γ-diamino acids was achieved in 6 steps starting from d-alanine. The analogues were then synthesized in solution phase and on solid phase. Biological activity tests showed that, compared with Gramicidin S, both analogues exerted diminished hemolytic activity while they retained interesting antibacterial activity.

We also recommend Trading Suppliers and Manufacturers of GRAMICIDIN C (cas 113-73-5). Pls Click Website Link as below: cas 113-73-5 suppliers

Prev:ArticleGramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles
Next:Effect of pyrrolidinium based ionic liquid on the channel form of gramicidin in lipid vesicles)