l-Histidine, arachidonic acid, biliverdin (cas 114-25-0), and l-cysteine-glutathione disulfide as potential biomarkers for cured pulmonary tuberculosis
-
Add time:08/23/2019 Source:sciencedirect.com
Lack of laboratory standards for cured tuberculosis (TB) can lead to early discharge of untreated TB patients from the hospital, resulting in increased risk of TB spread and of developing drug resistant Mycobacterium tuberculosis (Mtb). We used ultra-high performance liquid chromatography coupled with mass spectrometry (LC–MS) to detect heparin anticoagulant in plasma of untreated TB patients, two-month treated TB patients, cured TB subjects, and healthy controls. Screening of differentially expressed metabolites resulted in identification of four differentially expressed metabolites such as, l-Histidine, Arachidonic acid (AA), Biliverdin, and l-Cysteine-glutathione disulfide after 6 months of TB treatment. Among them, l-Cysteine-glutathione disulfide and AA could be identified after 2 months of TB treatment. We established a cured TB model with an area under the curve (AUC) of 0.909 (95% CI, 0.802–0.970), 86.2% sensitivity, and 85.2% specificity. The diagnostic model fitted from the four differential metabolites in combination (l-Histidine, AA, Biliverdin, and l-Cysteine-glutathione disulfide) can be used as potential biomarkers for cured TB. Our study provided laboratory standards for hospital discharge of TB patients, as well as experimental basis for evaluating the efficacy of anti-TB drugs.
We also recommend Trading Suppliers and Manufacturers of biliverdin (cas 114-25-0). Pls Click Website Link as below: cas 114-25-0 suppliers
Prev:Is it worth expending energy to convert biliverdin (cas 114-25-0) into bilirubin?
Next:ReviewRedox Functions of Heme Oxygenase-1 and biliverdin (cas 114-25-0) Reductase in Diabetes) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Singlet oxygen oxidation products of biliverdin (cas 114-25-0) IXα dimethyl ester08/30/2019
- Chiral recognition of bilirubin and biliverdin (cas 114-25-0) in liposomes and micelles08/29/2019
- Stabilization of structure in near-infrared fluorescent proteins by binding of biliverdin (cas 114-25-0) chromophore08/28/2019
- Reduced biliverdin (cas 114-25-0) reductase-A levels are associated with early alterations of insulin signaling in obesity08/27/2019
- Reviewbiliverdin (cas 114-25-0) reductase isozymes in metabolism08/26/2019
- Short CommunicationCrystal structure of a biliverdin (cas 114-25-0)-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation08/25/2019
- ReviewRedox Functions of Heme Oxygenase-1 and biliverdin (cas 114-25-0) Reductase in Diabetes08/24/2019
- Is it worth expending energy to convert biliverdin (cas 114-25-0) into bilirubin?08/22/2019
- Research paperModeling structure and excitation of biliverdin (cas 114-25-0)-binding domains in infrared fluorescent proteins08/21/2019