POLYVINYLPYRIDINE-N-OXIDE (cas 9045-81-2) and carboxymethyl cellulose inhibit mineral dust-induced production of reactive oxygen species by human macrophages

Add time:07/16/2019    Source:sciencedirect.com

Polyvinylpyridine-N-oxide (PVPNO) and carboxymethyl cellulose (CMC) are known to inhibit the cytotoxic effects of quartz particles and chrysotile asbestos fibers, respectively. The effect of PVPNO and CMC on mineral dust-induced production of reactive oxygen species (ROS) by human monocyte-derived macrophages was studied using lucigenindependent chemiluminescence. Ten micrograms of PVPNO inhibited the ROS production induced by 100 μg of quartz completely, but caused only 25% inhibition of the response to 100 μg of chrysotile. Ten micrograms of CMC inhibited the chrysotile-induced ROS production to 70%, but had a weak effect on the responses to quartz. Neither PVPNO nor CMC caused any inhibition of the ROS responses to serum-opsonized zymosan. PVPNO was bound to both quartz and chrysotile, but no binding of CMC to either dust could be detected. Neither PVPNO nor CMC had any superoxide scavenging effect. In conclusion, PVPNO and CMC seem to selectively modify mineral dust surface properties, which are of importance in the induction of ROS production by phagocytes. These observations may be useful in describing the pathogenesis of mineral dust-induced diseases, and may also have therapeutic implications.

We also recommend Trading Suppliers and Manufacturers of POLYVINYLPYRIDINE-N-OXIDE (cas 9045-81-2). Pls Click Website Link as below: cas 9045-81-2 suppliers

Prev:Complex-forming properties of polymethacrylic acid grafted to cellulose acetate on complexing with polyvinylpyridine N-oxide and copper ions
Next:Bisphenol A adsorption in aqueous medium by investigating organic and inorganic components of hybrid polymer (polyvinylpyridine/SiO2/APTMS))