Substituted 3-amino and/or 3-aminomethyl-3,4-dihydro-2H-1-benzopyrans: synthesis and biological activity

Add time:08/24/2019    Source:sciencedirect.com

A series of new 3-amino, 3-aminomethyl-5-alkoxy-3,4-dihydro-2H-1-benzopyran and 5′-alkoxy-3′,4′-dihydrospiro[piperazine-2,3′(2′H)-benzopyran] derivatives was prepared and evaluated for affinity at 5-HT1A, 5-HT2A and D2 receptors. Two of the compounds (Figure 3, Scheme 3, Figure 4, Scheme 4) can be considered as potent and selective 5-HT2A ligands. One compound (Figure 3, Scheme 3) demonstrated high affinity for 5-HT1A and D2 receptor binding sites and one compound (Figure 3, Scheme 2) proved to be a mixed 5-HT1A/5-HT2A ligand.

We also recommend Trading Suppliers and Manufacturers of 2H-1-Benzopyran-8-aMine, 3,4-dihydro- (cas 113722-25-1). Pls Click Website Link as below: cas 113722-25-1 suppliers

Prev:Synthesis, biological activity and quantitative structure-activity relationships of N-substituted-3,4-dihydro-2H-1-benzopyran derivatives
Next:Regular paperDetermination of β-cyclodextrin inclusion complex constants for 3,4-dihydro-2-H-1-benzopyran enantiomers by capillary electrophoresis)