Regular paperDetermination of β-cyclodextrin inclusion complex constants for 3,4-dihydro-2-H-1-benzopyran enantiomers by capillary electrophoresis

Add time:08/25/2019    Source:sciencedirect.com

Chiral separation of 3,4-dihydro-2H-1-benzopyran derivatives by capillary zone electrophoresis was achieved by employing β-cyclodextrin (β-CD) as chiral selector. The effects of electrolyte composition (β-cyclodextrin concentration, ionic strength and pH of the buffer) on the migration time, enantioselectivity, peak efficiency and resolution were investigated. As expected, there was an optimum β-CD concentration (Copt) which gave maximum enantioselectivity. The stability constant for the β-CD inclusion complex was determined for each enantiomer of two 3,4-dihydro-2H-1-benzopyran derivatives. For each solute, the experimental value of Copt agreed well with the value calculated from the equation [C]opt = 1/(KRKS)12, where we used experimental values for the inclusion complex constants (KR, KS). The enantiomeric separation of three 3,4-dihydro-2H-1-benzopyran derivatives was achieved using this optimization method, and baseline separation was obtained in less than 15 min with an efficiency of between 300 000 and 600 000 theoretical plates.

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