Original articleEfficient transesterification resolution of 2-(4-chlorophenyl)-4-hydroxytetrahydropyran with magnetically separable immobilized lipase

Add time:08/24/2019    Source:sciencedirect.com

We report an efficient kinetic resolution of racemic 2-(4-chlorophenyl)-4-hydroxytetrahydro-pyran (CLP-4-HTHP) via Pseudomonas cepacia lipase (PSL)-catalyzed transesterification, where PSL is immobilized on a core–shell MnFe2O4@SiO2-(CH2)3-NH2 carrier and used as a magnetically separable catalyst. The as-synthesized PSL/MnFe2O4@SiO2-(CH2)3-NH2 catalyst exhibits enhanced catalytic activity for resolving racemic CLP-4-HTHP to the corresponding optically pure (2R,4S)-CLP-4-HTHP compared to the free PSL. The ees for the former is 2.3 times larger than that for the latter under optimized conditions (99.4% and 44.1%, respectively), although the eep for them are same (99.2%). Meanwhile, the PSL/MnFe2O4@SiO2-(CH2)3-NH2 catalyst possesses a high saturate magnetization of 59.7 emu/g and could be easily recovered by magnetic separation and reused. The catalytic activity in six recycling tests did not significantly decrease, suggesting its great potential for industrial applications.

We also recommend Trading Suppliers and Manufacturers of (R)-1-(2-chlorophenyl)ethanol (cas 113724-48-4). Pls Click Website Link as below: cas 113724-48-4 suppliers

Prev:RESEARCH PAPEREfficient Synthesis of (S)-1-(2-chlorophenyl)ethanol in the Submerged Culture of Alternaria alternata Isolate
Next:Original research paperLow temperature optical absorption of polycrystalline thin films of α-quaterthiophene, α-sexithiophene and α-octithiophene, three model oligomers of polythiophene)