Highly stereoselective synthesis of cis-(2R,3S)-3-hydroxyproline
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Add time:08/21/2019 Source:sciencedirect.com
Allyltrimethylsilane (5) reacted with N-carbobenzoxy-O-tert-butyldimethylsilyl-L serinal (4) to give with high diastereoselectivity syn-adduct 3 which was subsequently transformed into cis-(2R,3S)-3-hydroxyproline (1).
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