Original articleSynthesis and cytotoxicity of cis-dichloroplatinum (II) complexes of (1S,3S)-1,2,3,4-tetrahydroisoquinolines

Add time:08/22/2019    Source:sciencedirect.com

A series of novel cisplatin-type platinum complexes with (1S,3S)-1,2,3,4-tetrahydroisoquinolines as the ligands were synthesized as potential anticancer agents in several steps starting from commercially available l-DOPA. The cytotoxicities of these compounds were tested against HCT-8, BEL-7402, A2780, MCF-7, Hela, A549 and BGC-823 cell lines by the MTT test. Some compounds exhibited better cytotoxic activity than cisplatin. The structure–activity relationship has been revealed.

► Eighteen novel cisplatin-type platinum complexes were synthesized. ► The substitution effect was studied. ► The cytotoxicities of these compounds were screened. ► Some compounds exhibited better cytotoxic activity than cisplatin. ► The structure–activity relationship has been revealed.

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