Synthesis of 2-arylbenzothiazoles via direct condensation between in situ generated 2-aminothiophenol from disulfide cleavage and carboxylic acids

Add time:08/23/2019    Source:sciencedirect.com

In this work we describe a simple and efficient general methodology for 2-arylbenzothiazole preparation employing disulfides and carboxylic acids. The reaction is promoted by tributylphosphine that acts both in disulfide bond cleavage and as activating agent for coupling with carboxylic acids. The reaction scope was studied using bis(2-aminophenyl)disulfide and different carboxylic acids with donor/withdrawing substituents, which resulted in the desired 2-arylbenzothiazole with moderate to good yields. The method was tested with success in preparation of the amyloid probe 2-(4-aminophenyl)-6-methoxybenzothiazole that employed a substituted bis(2-aminophenyl)disulfide.

We also recommend Trading Suppliers and Manufacturers of 6-BroMo-3-Methoxy-2-nitrobenzoic acid (cas 127971-97-5). Pls Click Website Link as below: cas 127971-97-5 suppliers

Prev:Tetrahedron report 1176Synthesis of fluorinated amino acid derivatives through late-stage deoxyfluorinations
Next:Data ArticleSynthesis, crystal structure and Hirshfeld surface of 2-Amino-3 benzyloxy pyridinium picrate (1:1))