Iminoheptitols as glycosidase inhibitors: Synthesis of α-homomannojirimycin (cas 127995-29-3), 6-epi-α-homomannojirimycin (cas 127995-29-3) and of a highly substituted pipecolic acid
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Add time:08/24/2019 Source:sciencedirect.com
In a search for a mannopyranose analogue which inhibits α-mannosidases but not α-fucosidases, α-homonojirimycin was prepared; the syntheses of 6-epi-α-homonojirimycin and of 2,6-dideoxy-2,6-imino-L-glycero-D-talo-heptonic acid (a highly substituted pipecolic acid) are also reported.
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- Intermediates for incorporation of tetrahydroxypipecolic acid analogues of α- and β-d-mannopyranose into combinatorial libraries: unexpected nanomolar-range hexosaminidase inhibitors. Synthesis of α- and β-homomannojirimycin (cas 127995-29-3)08/23/2019
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