Cytogenetic effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(50H)-furanone (MX) in rat peripheral lymphocytes in vitro and in vivo

Add time:08/26/2019    Source:sciencedirect.com

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) is a potent direct-acting Salmonella mutagen found in wood pulp chlorination effluents and chlorinated drinking water. In cultured rat peripheral lymphocytes, MX induced significant dose-related increases in sister-chromatid exchanges (SCEs) and chromosome aberrations at doses of 20–60 μg/ml and of 60–80 μg/ml, respectively. MX produced primarily chromatid-type as opposed to chromosome-type aberrations. The peripheral lymphocytes of male and female rats exposed to MX by gavage 5 days a week for 14–18 weeks showed significant dose-related increases in SCEs at both levels of exposure (30 and 45–75 mg/kg) in both sexes. The present results demonstrate for the first time that MX is genotoxic in vivo.

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