Chapter 8 - Indoles: As Multitarget Directed Ligands in Medicinal Chemistry

Add time:08/26/2019    Source:sciencedirect.com

Indoles constitute extensively explored heterocyclic ring systems with a wide range of applications in pathophysiological conditions such as cancer, microbial and viral infections, inflammation, depression, migraine, emesis, hypertension, and so on. Presence of an indole nucleus in amino acid tryptophan makes it prominent in phytoconstituents such as perfumes, neurotransmitters, auxins (plant hormones), indole alkaloids, and so on. The interesting molecular architecture of indoles makes them suitable candidates for drug development. This chapter provides an overview of the chemistry, biology, and toxicology of indoles, focusing on their application as multitarget directed drugs. This compiled information may serve as a benchmark for the alteration of existing ligands to design novel potent molecules with lesser side effects.

We also recommend Trading Suppliers and Manufacturers of 5-BENZYLOXY-6-METHYL INDOLE (cas 19500-00-6). Pls Click Website Link as below: cas 19500-00-6 suppliers

Prev:TEMPO-catalyzed oxidative dimerization and cyanation of indoles for the synthesis of 2-(1H-indol-3-yl)-3-oxoindoline-2-carbonitriles
Next:Cu-mediated C2-dehydrogenative homocoupling of indoles via C–H activation assisted by a removable N-pyrimidyl group)