Structural and conformational studies on 3,3′-bis [1,3-thiazolidin-4-one] derivatives with biological activity

Add time:08/23/2019    Source:sciencedirect.com

3,3′-(1,2-ethanediyl)bis[2-substituted-1,3-thiazolidin-4-one] derivatives display different biological activities depending on the configuration of the 2,2′ centers and on the substitution at C2, C2′. In this context, 3,3′-(1,2-ethanediyl)bis[2-(2′-(5′-methyl)thienyl)-1,3-thiazolidin-4-one] (6b) and 3,3′-(1,2-ethanediyl)bis[2-(3′-pyridyl)-1,3-thiazolidin-4-one] (8b) have been prepared. Their structural and conformational features, which can be related to the biological activity, have been investigated by X-ray diffraction and molecular modeling techniques.

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