Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity
-
Add time:08/27/2019 Source:sciencedirect.com
A novel α7 nAChR agonist, N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (3a, PHA-709829), has been identified for the potential treatment of cognitive deficits in schizophrenia. The compound shows potent and selective α7 in vitro activity, excellent brain penetration, good rat oral bioavailability and robust in vivo efficacy in a rat auditory sensory gating model.
We also recommend Trading Suppliers and Manufacturers of Furo[2,3-c]pyridine (cas 19539-50-5). Pls Click Website Link as below: cas 19539-50-5 suppliers
Prev:Research paperSynthesis of novel trifluoromethyl substituted furo[2,3-b]pyridine and pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as potential anticancer agents
Next:New C4- and C1-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: Evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- New C4- and C1-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: Evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform08/28/2019
- Research paperSynthesis of novel trifluoromethyl substituted furo[2,3-b]pyridine and pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as potential anticancer agents08/26/2019
- α,β-Unsaturated oxime as a new heterodiene for the diels alder reaction synthesis of furo [2,3-c] pyridine n-oxides08/25/2019
- Original articleSynthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives08/24/2019
- Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: Identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test08/23/2019
- Exploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis08/22/2019
- The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors08/21/2019
