Reactivity of 6-chloro-4- and 5-hydrazino-2-phenyl-3(2H)-pyridazinones with Vilsmeier reagent

Add time:08/23/2019    Source:sciencedirect.com

Reactions of 6-chloro-4- and 5-hydrazino-2-phenyl-3(2H)-pyridazinones (1–3) with dimethylformamide/phosphorus oxychloride afforded the pyrazolo[3,4-d]pyridazinones (4–6). Concurrently the formation of acyclic 6-chloro-4- and 5-(N, N-dimethylaminomethylidenehydrazino)-2-phenyl-3(2H)-pyridazinones (7–9) has been observed. A mechanism of these reactions is proposed. Compound 8 is shown to form unsolvated and inclusion compounds, both characterized by X-ray diffraction.

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