Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(Dppp (cas 110954-36-4))(L)]PF6 complexes

Add time:08/29/2019    Source:sciencedirect.com

The synthesis and characterization of ruthenium compounds of the type [RuCl2(NO)(dppp)(L)]PF6 [dppp = 1,3-bis(diphenylphosphino)propane; L = pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 μM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized = 200 μM).

We also recommend Trading Suppliers and Manufacturers of Dppp (cas 110954-36-4). Pls Click Website Link as below: cas 110954-36-4 suppliers

Prev:Carbon monoxide–ethylene copolymerization catalyzed by a Pd(OAc)2/Dppp (cas 110954-36-4)/formic acid system [Dppp (cas 110954-36-4)=1,3-bis(diphenylphosphino)propane]
Next:Terpolymerisation of 1-olefin and ethene with CO catalysed by the [PdCl2(Dppp (cas 110954-36-4))] complex in methanol as a solvent [Dppp (cas 110954-36-4) = 1,3-bis(diphenylphosphino)propane])