Rapid CommunicationThe R(−)-Enantiomer of Efonidipine Blocks T-type but Not L-type Calcium Current in Guinea Pig Ventricular Myocardium

Add time:08/26/2019    Source:sciencedirect.com

In guinea pig ventricular cardiomyocytes, the R(−)-enantiomer of efonidipine concentration-dependently blocked T-type Ca2+ current with 85% inhibition at 1 μM. In contrast, R(−)-efonidipine (1 μM) had no effect on the L-type Ca2+ current and Ca2+ transient in cardiomyocytes and contractile force in papillary muscles. Thus, R(−)-efonidipine is a highly selective blocker of the T-type Ca2+ current in native myocardia.

We also recommend Trading Suppliers and Manufacturers of Efonidipine Hydrochloride (cas 111011-79-1). Pls Click Website Link as below: cas 111011-79-1 suppliers

Prev:General paperEffects of Efonidipine Hydrochloride (cas 111011-79-1) (NZ-105), a new calcium antagonist, against acute renal failure in rats
Next:Synthesis of bifunctional chelating agents based on mono and diphosphonic derivatives of diethylenetriaminepentaacetic acid)