In vitro differentiation of human neuroblastoma cells induced by Sodium phenylacetate (cas 114-70-5)

Add time:08/26/2019    Source:sciencedirect.com

Sodium phenylacetate (NaPA) at concentrations ranging from 2 to 6 mM stimulated morphological differentiation of two human neuroblastoma cell lines IMR-32 and UKF-NB-3. These concentrations inhibited growth and DNA synthesis of the cells in a dose dependent manner without significant effect on cell viability. The differentiated cells showed pseudoganglia formation and extension of cellular processes. The morphological differentiation in both cell lines was accompanied by decreased expression of N-myc oncoprotein. These results suggest that NaPA at concentrations, which have been achieved in humans with no significant adverse effects, promotes differentiation of cultured human neuroblastoma cells in association with the reduced expression of the malignant phenotype.

We also recommend Trading Suppliers and Manufacturers of Sodium phenylacetate (cas 114-70-5). Pls Click Website Link as below: cas 114-70-5 suppliers

Prev:Regular ArticleExpression of Transcription Factors During Sodium phenylacetate (cas 114-70-5) Induced Erythroid Differentiation in K562 Cells☆
Next:Regular ArticleSuppression of tumourigenicity, and induction of differentiation of the canine mammary tumour cell line MCM -B2 by Sodium phenylacetate (cas 114-70-5))