Asymmetric synthesis and molecular docking study of enantiomerically pure pyrrolidine derivatives with potential antithrombin activity
-
Add time:07/15/2019 Source:sciencedirect.com
The (2R,4R,5S)- and (2S,4S,5R)-enantiomers of 4-(tert-butyl) 2-methyl 5-(4-bromophenyl)-pyrrolidine-2,4-dicarboxylate 3 were synthesized efficiently with an ee of >90% on a gram scale using a FAM-catalytic methodology. Subsequent modification afforded enantiopure N-((4-chlorophenyl)thio)acetyl pyrrolidine derivatives 4, which are potential thrombin inhibitors according to comprehensive molecular docking studies.
We also recommend Trading Suppliers and Manufacturers of Pyrrolidine, 1-[(4-bromophenyl)methyl]- (cas 4897-55-6). Pls Click Website Link as below: cas 4897-55-6 suppliers
Prev:Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains
Next:Synthesis and anticonvulsant properties of new N-[(4-arylpiperazin-1-yl)-methyl] derivatives of 3-aryl pyrrolidine-2,5-dione and 2-aza-spiro[4.4]nonane-1,3-dione) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Diastereoselective construction of spirocyclic pyrrolidines bearing two quaternary centers via CuII-P, N-Ligand catalyzed 1,3-dipolar cycloaddition07/19/2019
- Cu(OTf)2 catalyzed cross-coupling reaction of 1,3-dicarbonyl derivatives with 2-oxo-1-pyrrolidine compounds07/18/2019
- Synthesis of chiral 2-(anilinophenylmethyl)pyrrolidines and 2-(anilinodiphenylmethyl)pyrrolidine and their application to enantioselective borane reduction of prochiral ketones as chiral catalysts07/17/2019
- Synthesis and anticonvulsant properties of new N-[(4-arylpiperazin-1-yl)-methyl] derivatives of 3-aryl pyrrolidine-2,5-dione and 2-aza-spiro[4.4]nonane-1,3-dione07/16/2019
- Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains07/14/2019
- Spirooxindole-pyrrolidine heterocyclic hybrids promotes apoptosis through activation of caspase-307/13/2019
