The LIV-I/LS system as a determinant of AZASERINE (cas 115-02-6) sensitivity of Escherichia coli K-12

Add time:08/23/2019    Source:sciencedirect.com

The growth of Escherichia coli is inhibited by an antibiotic compound, AZASERINE (cas 115-02-6) (O-diazoacetyl-l-serine). Previous studies revealed the biochemical properties of azaserine, which involves inhibition of various enzymatic reactions as well as introduction of DNA breakage. However, genetically, nothing has been elucidated except that all the azaserine-resistant strains isolated so far carry lesions in the aroP gene as a primary determinant. Here, we demonstrate that, in addition to AroP, the LIV-I/LS system, an ATP-binding cassette type transporter, is involved in azaserine sensitivity of E. coli, by genetic analysis and transport studies, in which Ki value for azaserine was determined to be ∼10−3 M.

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