Mutagenicity of O-diazoacetyl-l-serine (AZASERINE (cas 115-02-6)) and 6-diazo-5-oxo-l-norleucine (DON) in a soybean test system

Add time:08/29/2019    Source:sciencedirect.com

The mutagenicity of O-diazocetyl-l-serine (azaserine) and 6-diazo-5-oxo-l-norleucine (DON), glutamine analogues, were assayed in heterozygous soybean plants (Y11y11), according to the appearance of mutational spots (yellow, dark green and twin) on the leaves. The mutagenicity of azaserine was detected at 0.1 mg/ml, and that of DON, at 0.05 mg/ml. DON was strongly cytotoxic at doses exceeding 0.1 mg/ml. After azaserine and DON treatment, large spots which occupied more than half the leaflet were found in the first and second compound leaves. The glutamine analogues increased the frequency of yellow spots much more than dark green spots or twin spots. Light green spots were observed on y11y11 plants. Azaserine and DON induce somatic crossing over, point mutation and segmental loss as major effects.

We also recommend Trading Suppliers and Manufacturers of AZASERINE (cas 115-02-6). Pls Click Website Link as below: cas 115-02-6 suppliers

Prev:The function of γ-glutamyl transpeptidase as a determinant in cell sensitivity to AZASERINE (cas 115-02-6) toxicity
Next:The stoichiometric fate of AZASERINE (cas 115-02-6) metabolized in vitro by tissues from AZASERINE (cas 115-02-6)-treated dogs and mice☆)