Rapid communicationTrichloroethanol (cas 115-20-8) inhibits ATP-induced membrane currents in cultured HEK 293-hP2X3 cells
-
Add time:08/28/2019 Source:sciencedirect.com
Membrane currents in response to the application of α,β-methylene ATP (α,β-meATP) were recorded by the whole-cell patch-clamp technique in human embryonic kidney 293 cells transfected with the human P2X3 receptor (HEK 293-hP2X3 cells). Trichloroethanol, the biologically active metabolite of chloral hydrate, but not ethanol itself concentration-dependently and reversibly inhibited the current responses. It was concluded that the reported analgesic effect of chloral hydrate may be due to the interruption of pain transmission in dorsal root ganglia expressing P2X3 receptors.
We also recommend Trading Suppliers and Manufacturers of Trichloroethanol (cas 115-20-8). Pls Click Website Link as below: cas 115-20-8 suppliers
Prev:Trichloroethanol (cas 115-20-8) up-regulates matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in HaCaT cells
Next:Evaluation of dynamic headspace with gas chromatography/mass spectrometry for the determination of 1,1,1-trichloroethane, Trichloroethanol (cas 115-20-8), and trichloroacetic acid in biological samples) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Short communicationInhibition by chloral hydrate and Trichloroethanol (cas 115-20-8) of AMPA-induced Ca2+ influx in rat cultured cortical neurones08/31/2019
- Detection of photolytically produced hydroxyl radicals by reaction with 2,2,2-Trichloroethanol (cas 115-20-8)08/30/2019
- Evaluation of dynamic headspace with gas chromatography/mass spectrometry for the determination of 1,1,1-trichloroethane, Trichloroethanol (cas 115-20-8), and trichloroacetic acid in biological samples08/29/2019
- Trichloroethanol (cas 115-20-8) up-regulates matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in HaCaT cells08/27/2019
- Trichloroethanol (cas 115-20-8) enhances the activity of recombinant human TREK-1 and TRAAK channels08/26/2019
- Trichloroethylene and Trichloroethanol (cas 115-20-8)-induced formic aciduria and renal injury in male F-344 rats following 12 weeks exposure08/25/2019
- Rapid communicationTrichloroethanol (cas 115-20-8) impairs NMDA receptor function in rat mesencephalic and cortical neurones08/24/2019
- 2,2,2-Trichloroethanol (cas 115-20-8) lengthens the circadian period of Bmal1-driven circadian bioluminescence rhythms in U2OS cells08/23/2019
- Trichloroethylene oxidative metabolism in plants: the Trichloroethanol (cas 115-20-8) pathway08/22/2019