Efficient construction of 8-membered ring framework of vinigrol (cas 111025-83-3) through SmI2-induced coupling cyclization

Add time:08/29/2019    Source:sciencedirect.com

The 8-membered ring framework of vinigrol (cas 111025-83-3), a unique tricyclic diterpene isolated as a novel antihypertensive compound from a culture of Virgaria nigra, was efficiently synthesized employing an SmI2-induced intramolecular coupling. It is particularly noteworthy that the 8-membered carbocycle was cyclized in quantitative yields under non-high-dilution conditions.

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