Asymmetric synthesis of a new simplified dynemicin analogue equipped with a handle
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Add time:08/24/2019 Source:sciencedirect.com
The new simplified dynemicin analogue 16 was prepared enantio- and diastereoselectively in 17 steps starting from monoacetate (S) 7. It is equipped with a side arm containing a protected primary alcoholic function (`handle'), which can be used for conjugation with DNA-complexing agents or for devising new types of trigger.
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