MgCl2 catalyzed one-pot synthesis of 2-hydroxy-3-((5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(phenyl)methyl)naphthalene-1,4-dione derivatives in EG

Add time:08/24/2019    Source:sciencedirect.com

A green and convenient synthetic method has been described for the synthesis of 2-hydroxy-3-((5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(phenyl)methyl)naphthalene-1,4-dione derivatives by a one-pot, four-component reaction of aromatic aldehydes, 2-hydroxy-1,4-naphthoquinone, hydrazine derivatives, and ethyl acetoacetate catalyzed by MgCl2 in ethylene glycol. Simplicity, short reaction time, high yield, and an eco-friendly catalyst are the main advantages of this method.

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