A new structural alert for benzimidazoles: 2,6-Dimethylphenyl substituents increase mutagenic potential and time-dependent CYP3A4 inhibition risk
-
Add time:08/24/2019 Source:sciencedirect.com
A series of 2-[(2,6)-dimethylphenyl]benzimidazole analogs displayed strong potential for mutagenicity following metabolic activation in either TA98 or TA100 Salmonella typhimurium strains. The number of revertants was significantly reduced by replacing the 2,6-dimethylphenyl group with a 2,6-dichlorophenyl moiety. Time-dependent CYP3A4 inhibition was also observed with a compound containing a 2-[(2,6)-dimethylphenyl] benzimidazole ring, implying risk for this scaffold to generate reactive metabolites.
We also recommend Trading Suppliers and Manufacturers of 1-(2,6-DIMETHYLPHENYL)-1H-PYRROLE-3-CARBALDEHYDE (cas 132688-31-4). Pls Click Website Link as below: cas 132688-31-4 suppliers
Prev:Synthesis of tris(4-amino-2,6-dimethylphenyl)borane and facile extension of its π-conjugated system by utilizing the reactivity of the amino groups
Next:Original articleSynthesis and anticonvulsant activity of two N-(2,6-dimethylphenyl)pyridinedicarboximides) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Effect of organic vapors on Au, Ag, and Au–Ag alloy nanoparticle films with adsorbed 2,6-dimethylphenyl isocyanide08/28/2019
- Synthesis and spectroscopic studies of diorganotin derivatives with 2-[(2,6-dimethylphenyl)amino]benzoic acid. Crystal and molecular structure of the first complexes of 2-[(2,6-dimethylphenyl)amino]benzoic acid. Crystal and molecular structures of 1,2:3,4-di-μ2-2-[(2,6-dimethylphenyl)amino]-benzoato-O,O-1,3-bis-2-[(2,6-dimethylphenyl)amino]benzoato-O-1,2,4:2,3,4-di-μ3-oxo-tetrakis[di-butyltin(IV)] and bis-2-[(2,6-dimethylphenyl)amino]benzoato-di-n-butyltin(IV)08/27/2019
- Au-to-CO electron transfer evidenced by surface-enhanced Raman scattering of 2,6-dimethylphenyl isocyanide08/26/2019
- Original articleSynthesis and anticonvulsant activity of two N-(2,6-dimethylphenyl)pyridinedicarboximides08/25/2019
- Synthesis of tris(4-amino-2,6-dimethylphenyl)borane and facile extension of its π-conjugated system by utilizing the reactivity of the amino groups08/23/2019
