Chymase processes big-endothelin-2 to endothelin-2-(1–31) that induces contractile responses in the isolated monkey trachea

Add time:08/23/2019    Source:sciencedirect.com

Purified monkey chymase cleaved the Tyr31–Gly32 bond of big-endothelin-1 and big-endothelin-2 to yield endothelin-1-(1–31) and endothelin-2-(1–31), respectively. In the isolated monkey trachea, endothelin-1-(1–31) and endothelin-2-(1–31), as well as big-endothelin-1 and big-endothelin-2, induced contractile responses. Chymostatin, which inhibits chymase, suppressed the contractile response induced by big-endothelin-2 to 16.6% but not the responses induced by big-endothelin-1, endothelin-1-(1–31) and endothelin-2-(1–31). These results suggest that the contractile response of big-endothelin-2 is predominantly dependent on the conversion of big-endothelin-2 to endothelin-2-(1–31) by chymase.

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