Fluorinated intermediates in the synthesis of β-2-fluorodideoxynucleosides
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Add time:08/28/2019 Source:sciencedirect.com
A new and efficient method is described for the preparation of (3S-cis)-3-fluoro-5-[(t-butyldimethylsiloxy) methyl]-2-tetrahydrofuranone (1b), a valuable intermediate for the synthesis of fluorinated nucleosides. The conversion of 1b to 1-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl) thymine (5) is described.
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