Immunolocalization of β-catenin and Lef-1 during postnatal hair follicle development in mice

Add time:08/27/2019    Source:sciencedirect.com

It is well recognized that the Wnt pathway, in which β-catenin and Lef-1 are important factors, is associated with many physiological processes, including embryogenesis and postnatal development. The Wnt pathway also plays a critical role in the development of skin. It regulates the formation of the dorsal dermis and epidermal appendages in the skin and the activity of epithelial stem cells. In this study, we investigated the presence and localization of β-catenin and Lef-1 in murine hair follicles through the first postnatal month, which encompasses the first hair cycle in mice, using Western blotting and immunohistochemistry. Our results show that β-catenin and Lef-1 are expressed during all stages in a hair cycle, most strongly in the anagen and weakly in the catagen and telogen phases. The results also suggest that the β-catenin-Lef-1 complex may regulate hair follicle cycling. This process will be of considerable interest to future studies.

We also recommend Trading Suppliers and Manufacturers of LEF-1 protein (cas 138415-19-7). Pls Click Website Link as below: cas 138415-19-7 suppliers

Prev:The transcription factor LEF-1 induces an epithelial–mesenchymal transition in MDCK cells independent of β-catenin
Next:LEF-1 activates the transcription of E2F1)