LEF-1 activates the transcription of E2F1
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Add time:08/28/2019 Source:sciencedirect.com
LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further β-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that LEF-1, except for its function in Wnt signaling, may play a distinct role via activating the transcription of E2F1.
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