Original ArticleSafety and effectiveness of sodium colistimethate (cas 12705-41-8)-loaded nanostructured lipid carriers (SCM-NLC) against P. aeruginosa: in vitro and in vivo studies following pulmonary and intramuscular administration
-
Add time:08/24/2019 Source:sciencedirect.com
The usefulness of nanotechnology to increase the bioavailability of drugs and decrease their toxicity may be a tool to deal with multiresistant P. aeruginosa (Mr-Pa) respiratory infections. We describe the preparation and the in vivo efficacy and safety of sodium colistimethate-loaded nanostructured lipid carriers (SCM-NLC) by the pulmonary and intramuscular routes. Nanoparticles showed 1-2 mg/L minimum inhibitory concentration against eight extensively drug-resistant P. aeruginosa strains. In vivo, SCM-NLC displayed significantly lower CFU/g lung than the saline and similar to that of the free SCM, even the dose in SCM-NLC group was lower than free SCM. There was no tissue damage related to the treatments. Biodistribution assessments showed a mild systemic absorption after nebulization and a notorious absorption after IM route. Altogether, it could be concluded that SCM-NLC were effective against P. aeruginosa in vivo, not toxic and distribute efficiently to the lung and liver after pulmonary or intramuscular administrations.
We also recommend Trading Suppliers and Manufacturers of colistimethate (cas 12705-41-8). Pls Click Website Link as below: cas 12705-41-8 suppliers
Prev:Short communicationPotential pitfalls in LC-MS/MS quantification of colistin for therapeutic drug monitoring of patients treated with colistimethate (cas 12705-41-8)
Next:Short communicationA simple method for assaying colistimethate (cas 12705-41-8) sodium in pharmaceutical aerosol samples using high performance liquid chromatography) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- NotesPolymyxin B and colistimethate (cas 12705-41-8) are comparable as to efficacy and renal toxicity08/28/2019
- Sodium colistimethate (cas 12705-41-8) loaded lipid nanocarriers for the treatment of Pseudomonas aeruginosa infections associated with cystic fibrosis08/27/2019
- Rapid communicationStability of colistimethate (cas 12705-41-8) sodium in a disposable elastomeric infusion device08/26/2019
- Short communicationA simple method for assaying colistimethate (cas 12705-41-8) sodium in pharmaceutical aerosol samples using high performance liquid chromatography08/25/2019
- Short communicationPotential pitfalls in LC-MS/MS quantification of colistin for therapeutic drug monitoring of patients treated with colistimethate (cas 12705-41-8)08/23/2019