The structure of hikizimycin (cas 12706-94-4) : Part I. Identification of 3-amino-3-deoxy-D-glucose and cytosine as structural components☆
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Add time:08/25/2019 Source:sciencedirect.com
The molecular formula for hikizimycin (cas 12706-94-4), a new antibiotic isolated from Streptomyces A-5, is now established as C21H37N5O14. Evidence in support of the occurrence of 3-amino-3-deoxy-D-glucose and cytosine residues in the antibiotic molecules is presented. Methanolysis of N,N′-diacetylhikizimycin gave mainly two components. Fragment A was characterized as methyl 3-amino-3-deoxy-D-glucopyranoside by its conversion into the known methyl 3-acetamido-2,4,6-tri-O-acetyl-3-deoxy-α-D-glucopyranoside. Fragment B, on catalytic hydrogenation followed by acid hydrolysis, gave tetrahydropyrimidin-2-one, characterized as its picrate, thus establishing the presence of a cytosine residue in hikizimycin.
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