Piperidines from acid-catalysed cyclisations: Pitfalls, solutions and a new ring contraction to pyrrolidines
-
Add time:08/28/2019 Source:sciencedirect.com
The success of acid-catalysed cyclisations of alka-4-enylamine derivatives to piperidines depends very much on the nature of the amine protecting group: while carbamates and related amides can usually be readily and cleanly transformed, the corresponding sulfonamides react further by ring contraction leading to pyrrolidines, especially when such substrates are sterically crowded.
We also recommend Trading Suppliers and Manufacturers of 4-(PYRROLIDINE-1-SULFONYL)-BENZOIC ACID (cas 19580-33-7). Pls Click Website Link as below: cas 19580-33-7 suppliers
Prev:Amino acid ferrocene conjugates using sulfonamide linkages
Next:2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- 2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists08/29/2019
- Amino acid ferrocene conjugates using sulfonamide linkages08/27/2019
- New class of P-stereogenic chiral Brønsted acid catalysts derived from chiral phosphinamides08/26/2019
- Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases08/25/2019
- Original articleInfluence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -708/24/2019
-
Health and Chemical more >