2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists
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Add time:08/29/2019 Source:sciencedirect.com
High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.
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