Synthesis of trifluoromethylated pyrrolidines via decarboxylative [3+2] cycloaddition of non-stabilized N-unsubstituted azomethine ylides
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Add time:08/28/2019 Source:sciencedirect.com
A new method for synthesis of trifluoromethylated and pyrrolidinedione-fused pyrrolidines is developed through a three-component and decarboxylative [3 + 2] cycloaddition of non-stabilized N-unsubstituted azomethine ylides with commercially available trifluoroacetophenones. This efficient and economic synthesis only produces stoichiometric amount of CO2 and H2O as byproducts.
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