Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists
-
Add time:08/29/2019 Source:sciencedirect.com
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was shown to be the cis-3R,4S isomer, as exemplified by the potent dual PPARα/γ agonists 3k and 4i. The N-4-trifluoromethyl-pyrimidinyl pyrrolidine acid analog 4i was efficacious in lowering fasting glucose and triglyceride levels in diabetic db/db mice.
We also recommend Trading Suppliers and Manufacturers of Pyrrolidine, 1-[4-(trifluoroMethyl)phenyl]- (cas 113845-68-4). Pls Click Website Link as below: cas 113845-68-4 suppliers
Prev:Synthesis of trifluoromethylated pyrrolidines via decarboxylative [3+2] cycloaddition of non-stabilized N-unsubstituted azomethine ylides
Next:5α-Pregnane-3β,7α,17,20α- and -20β-tetrols as metabolites of progesterone and 17-hydroxyprogesterone in carp (Cyprinus carpio) ovarian incubations) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis of trifluoromethylated pyrrolidines via decarboxylative [3+2] cycloaddition of non-stabilized N-unsubstituted azomethine ylides08/28/2019
- Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model08/27/2019
- Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones08/26/2019
- Short communicationSynthesis and anticonvulsant activity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 3-phenyl-pyrrolidine-2,5-dione08/25/2019
- Nucleophilic 5-endo-trig cyclization of 2-(trifluoromethyl)allylic metal enolates and enamides: Synthesis of tetrahydrofurans and pyrrolidines bearing exo-difluoromethylene units08/24/2019
