Metal-free one-pot synthesis of benzofurans with ynones and quinones through aza-Michael/Michael/annulation sequence

Add time:08/24/2019    Source:sciencedirect.com

A convenient metal-free one-pot synthesis of benzofuran derivatives starting from simple ynones has been developed. Various functionalized benzofurans closely related to bioactive molecules can be obtained in moderate to good yields (up to 90%) through aza-Michael/Michael/annulation sequence. Preparative scale synthesis of benzofurans has also been successfully achieved. The application of the benzofuran products has been shown by easy transformations to highly functionalized molecules holding significant promise for medicinal chemistry and organic material chemistry.

We also recommend Trading Suppliers and Manufacturers of (4-chlorophenyl)(5-hydroxy-1-benzofuran-3-yl)methanone (cas 17249-67-1). Pls Click Website Link as below: cas 17249-67-1 suppliers

Prev:Short communicationSynthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives
Next:Short communicationSynthesis and antimicrobial evaluation of new benzofuran derivatives)