Short communicationSynthesis and antimicrobial evaluation of new benzofuran derivatives

Add time:08/25/2019    Source:sciencedirect.com

Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39–3.12 μg/mL), which were better than the control drugs.

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