A new efficient synthesis of 2-phenyl-4-oxo-1-amino-cyclohexanecarboxylic acids

Add time:08/25/2019    Source:sciencedirect.com

The adducts obtained through the Diels-Alder cycloadditions of (Z)-2-phenyl-4-benzyliden-5(4H)-oxazolone 1 with Danishefsky's diene and of methyl (E)-2-cyanocinnamate 9 with 2-methoxy-1,3-butadiene, were subsequently transformed allowing the synthesis of both stereoisomers of 2-phenyl-4-oxo-1-aminocyclohexanecarboxylic acid (8 and 20).

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