Chapter 7 Thiazoles and benzothiazoles

Add time:08/27/2019    Source:sciencedirect.com

Publisher SummaryThiazoles play a prominent role in nature. For example, the thiazolium ring present in vitamin B1 serves as an electron sink and its coenzyme form is important for the decarboxylation of α-keto-acids. Furthermore, thiazoles are useful building blocks in pharmaceutical agents as exemplified by 2-(4-chlorophenyl) thiazole-4-acetic acid, a synthetic anti-inflammatory agent. Thiazole is a π-electron-excessive heterocycle. The electronegativity of the N-atom at the 3-position makes C (2) partially electropositive and therefore susceptible to nucleophilic attack. In contrast, electrophilic substitution of thiazoles preferentially takes place at the electron-rich C (5) position. More relevant to palladium chemistry, 2-halothiazoles and 2-halobenzothiazoles are prone to undergo oxidative addition to Pd (0) and the resulting σ-heteroaryl palladium complexes participate in various coupling reactions. Even 2-chlorothiazole and 2-chlorobenzothiazole are viable substrates for Pd-catalyzed reactions. Two of the most frequently used approaches for halothiazole synthesis are direct halogenation of thiazoles and the Sandmeyer reaction of aminothiazoles. The third method, an exchange between a stannylthiazole and a halogen, is not practical in the context of palladium chemistry simply because the stannylthiazole can be used directly in a Stille coupling.

We also recommend Trading Suppliers and Manufacturers of 4-BROMO-2-(TRIMETHYLSILYL)THIAZOLE (cas 108306-53-2). Pls Click Website Link as below: cas 108306-53-2 suppliers

Prev:Synthesis of pyridazine and thiazole analogs as SGLT2 inhibitors
Next:4.06 - Thiazoles)