3-hydroxymethyl-4-aryl-4-hydroxybutanoic acid lactones : Podophyllotoxin analogs

Add time:09/01/2019    Source:sciencedirect.com

The biological activity of podophyllotoxin has been expressed in terms of the alkylating potential of its “swinging lactone” functionality. The synthesis and characterization of the two isomeric lactones (X and XI) of 3-hydroxymethyl-4-(3,4-methylenedioxyphenyl)-4-hydroxybutanoic acid, embodying the lowest common denominator of this functionality, are described. The attempted preparation of 4.4-diaryl analogs of these dihydroxyacid lactones revealed a novel oxidation-reduction cycle, relating 3-(4,4′-dimethoxybenzhydrylidene)-4-hydroxybutanoic acid lactone (XX) to 3-(α-hydroxy-4,4′-dimethoxybenzhydryl)-4-hydroxy-2-butenoic acid lactone (XXII).

We also recommend Trading Suppliers and Manufacturers of 3-hydroxybutanoic acid, 4-hydroxybutanoic acid (cas 117068-64-1). Pls Click Website Link as below: cas 117068-64-1 suppliers

Prev:Lipase-catalyzed resolution of esters of 4-chloro-3-hydroxybutanoic acid: effects of the alkoxy group and solvent on the enantiomeric ratio
Next:Polymer communicationHetero-stereocomplex formation between substituted poly(lactic acid)s with linear and branched side chains, poly(l-2-hydroxybutanoic acid) and poly(d-2-hydroxy-3-methylbutanoic acid))